STYLAGE® S BI-FLEX® with Lidocaine

Product Specifications Active Ingredient: Hyaluronic acid (cross-linked) 16mg/g; Mannitol 9mg/mL; Lidocaine 3mg/mL Regulatory Status: CE-marked (EU); practitioners should verify current US FDA status and other applicable jurisdictions independently Molecular Type: Cross-linked hyaluronic acid (IPN-Like Technology™) with mannitol and lidocaine Strength: 16mg/g HA | 9mg/mL Mannitol | 3mg/mL Lidocaine Dosage Form: Injectable gel — 2 × 0.8mL prefilled syringes (BI-FLEX® syringe system, rebranded from Bi-SOFT®) + 4 × 30G ½ needles Manufacturer: Laboratories VIVACY Brand: STYLAGE® Country of Origin: France Storage Requirements: Store below 25°C; do not freeze; protect from direct sunlight Intended Use: Fine line correction, superficial wrinkle treatment, skin texture refinement — for licensed aesthetic professionals Who Is STYLAGE® S BI-FLEX® with Lidocaine Indicated For, and What Is the BI-FLEX® Syringe? STYLAGE® S BI-FLEX® with Lidocaine is specifically formulated for superficial dermal indications, making it suitable for patients seeking subtle correction of early facial aging signs and surface irregularities. Its rheological profile supports precise placement in delicate treatment areas where natural-looking refinement is desired. Common treatment areas include periorbital lines, perioral and smoker’s lines, superficial skin texture irregularities, and the superficial components of nasolabial folds and marionette lines.  The product is not indicated for deep wrinkle correction, significant volume loss, or facial volumization procedures. Patient Suitability Considerations Appropriate patient selection is essential for successful clinical outcomes. Because STYLAGE® S BI-FLEX® with Lidocaine is designed specifically for superficial correction, practitioners must comprehensively evaluate the patient before proceeding. For patients presenting with both superficial and deeper structural aging concerns, STYLAGE® S can be effectively incorporated into multi-layer treatment protocols alongside higher-density dermal fillers. When evaluating a patient for this formulation, practitioners should assess: Skin Condition: Overall tissue health, elasticity, and hydration levels. Skin Type and Thickness: Ensuring the dermis is suitable for a low-viscosity filler without risking visibility. Treatment Area: Confirming the target zones match superficial indications (e.g., perioral or periorbital lines). Degree of Correction: Verifying that the patient’s expectations align with subtle refinement rather than significant volume restoration. The BI-FLEX® Syringe System The BI-FLEX® syringe system succeeds the former Bi-SOFT® platform with improvements focused on practitioner control and patient safety, particularly during superficial injections where precise placement is essential. The redesigned system offers improved ergonomics, greater injection precision, and enhanced safety for practitioners and patients. These features support consistent, controlled delivery in delicate treatment areas requiring meticulous technique. STYLAGE® S BI-FLEX® with Lidocaine is intended exclusively for licensed aesthetic medicine professionals trained in injectable procedures, facial anatomy, and complication management. Strict aseptic technique, appropriate injection depth, and avoidance of intravascular injection are essential. How Does STYLAGE® S BI-FLEX® with Lidocaine Work? Once injected into the superficial dermis, the cross-linked hyaluronic acid (HA) matrix binds water molecules and integrates seamlessly into the surrounding tissue. This process delivers immediate mechanical smoothing of superficial wrinkles while simultaneously enhancing hydration and skin quality at the injection site. The clinical performance of STYLAGE® S BI-FLEX® is driven by three synergistic components: IPN-Like Technology™: Incorporates two interlocked HA polymer networks. This unique dual-network structure enhances gel cohesivity and resistance to mechanical deformation, supporting a smooth, even distribution within delicate superficial tissue planes. Mannitol (9mg/mL): Functions as a potent free-radical scavenger. By neutralizing reactive oxygen species (ROS) at the injection site, it actively limits the oxidative degradation of the HA matrix, contributing to longer-lasting clinical outcomes. Lidocaine (3mg/mL): An amide-type local anesthetic that significantly reduces patient discomfort during administration. This is particularly valuable when treating highly sensitive zones like the perioral (lip line) and periorbital (eye area) regions. Like other HA-based injectable fillers, the STYLAGE® S matrix remains fully dissolvable. It can be rapidly degraded using hyaluronidase if correction, asymmetry adjustment, or emergency vascular reversal becomes necessary. How Is STYLAGE® S BI-FLEX® with Lidocaine Administered, and What Are the Safety Considerations? STYLAGE® S BI-FLEX® with Lidocaine should be administered using superficial intradermal placement by qualified aesthetic professionals familiar with facial anatomy, vascular safety protocols, and complication management. The BI-FLEX® precision system supports controlled product delivery in fine treatment areas. Lidocaine is co-formulated at 3mg/mL; a topical anesthetic may also be applied at the practitioner’s discretion. Following treatment, patients should avoid excessive sun exposure and intense heat until redness and swelling resolve. Bruising at the injection site may occur and typically resolves within a few days. Common Side Effects Redness Swelling Tenderness Bruising at the injection site These effects are generally mild and resolve within a few days without intervention. Serious Adverse Events Although uncommon, serious complications including vascular occlusion, skin necrosis, tissue ischemia, and severe hypersensitivity reactions have been reported with injectable dermal fillers. Practitioners must be trained to recognize and manage these events. Patients should be screened for allergies to hyaluronic acid or amide-type anesthetics before treatment, and full safety guidance should be reviewed within the manufacturer’s Instructions for Use (IFU). What Is the Regulatory Status of STYLAGE® S BI-FLEX® with Lidocaine? STYLAGE® S BI-FLEX® with Lidocaine is manufactured in France by Laboratories VIVACY and carries CE marking for professional aesthetic use in applicable European markets. The product is restricted to licensed medical professionals and registered aesthetic clinics trained in injectable procedures. Regulatory requirements may differ across jurisdictions, and practitioners should independently verify local approval, importation, and procurement regulations before clinical use. Practitioners who wish to buy dermal fillers or buy STYLAGE® may contact Medical Spa Rx’s professional support team for sourcing information and documentation support. Practitioners evaluating buy STYLAGE® S BI-FLEX® wholesale options should confirm that suppliers comply with applicable storage, transport, and regulatory standards. Regulatory information is current as of mid 2026; practitioners should verify local requirements before procurement or use. For sourcing guidance, contact Medical Spa Rx’s professional support team.