STYLAGE® M BI-FLEX® with Lidocaine

Product Specifications Active Ingredient: Hyaluronic acid (cross-linked) 20mg/g; Mannitol 9mg/mL; Lidocaine 3mg/mL Regulatory Status: CE-marked (EU); practitioners should verify current US FDA status and other applicable jurisdictions independently Molecular Type: Cross-linked hyaluronic acid (IPN-Like Technology™) with mannitol and lidocaine Strength: 20mg/g HA | 9mg/mL Mannitol | 3mg/mL Lidocaine Dosage Form: Injectable gel — 2 × 1mL prefilled syringes (patented syringe system; formerly known as Bi-SOFT®) + 2 × 30G ½ needles Manufacturer: Laboratories VIVACY Brand: STYLAGE® Country of Origin: France Storage Requirements: Store below 25°C; do not freeze; protect from direct sunlight Intended Use: Moderate wrinkle correction, volume restoration, hand rejuvenation — for licensed aesthetic professionals Who Is STYLAGE® M BI-FLEX® with Lidocaine Indicated For? STYLAGE® M BI-FLEX® with Lidocaine injection is designed for licensed aesthetic medicine professionals treating patients with moderate signs of facial aging, volume loss, and soft tissue deficiencies. Its balanced rheological profile allows practitioners to address multiple treatment indications while maintaining natural-looking results. Moderate Wrinkle Correction The product is commonly used for correcting moderate to deep wrinkles, including nasolabial folds, marionette lines, and other moderate facial creases. For these indications, injections are typically placed in the mid-dermis to provide structural support and reduce wrinkles. Volume Restoration The filler may also be used to restore volume in areas affected by age-related soft tissue loss, including the cheeks, chin, perioral region, and lips. Depending on the anatomical region and desired outcome, practitioners may inject into the mid-to-deep dermis or subcutaneous plane. Hand Rejuvenation A notable clinical indication for STYLAGE® M BI-FLEX® with Lidocaine is hand rejuvenation. Age-related volume loss on the dorsum of the hands can contribute to a more aged appearance by increasing the visibility of tendons and veins. Appropriate injection techniques may help restore a smoother and fuller appearance while maintaining natural hand mobility. Patient Suitability Considerations Prior to treatment, practitioners should evaluate the severity of volume loss, skin quality and elasticity, skin type, prior dermal filler treatments, patient expectations, and specific treatment-area requirements. Many professionals evaluating whether STYLAGE® is a good filler consider its combination of IPN-Like Technology™, a mannitol-enhanced formulation, a patented syringe design, and its established use in aesthetic medicine.  STYLAGE® products are CE-marked for use in applicable European markets; practitioners should verify current regulatory standing in the United States and other jurisdictions before procurement or clinical use. As with all injectable dermal fillers, patient selection remains essential for achieving optimal outcomes. How Does STYLAGE® M BI-FLEX® with Lidocaine Work? STYLAGE® M BI-FLEX® with Lidocaine combines cross-linked hyaluronic acid with advanced formulation technologies to restore facial volume, improve hydration, and soften moderate to deep wrinkles. Once injected into the dermis, the cross-linked hyaluronic acid integrates with surrounding tissues and attracts water, helping replenish lost volume while supporting smoother, more youthful-looking skin. A key feature of this STYLAGE® dermal filler is its proprietary IPN-Like Technology™, which utilizes two interlocked hyaluronic acid polymer networks. This structure enhances cohesivity, elasticity, resistance to deformation, and tissue integration, allowing the product to perform consistently across multiple facial treatment areas. The formulation also contains 9mg/mL of mannitol, a free radical scavenger that helps reduce oxidative degradation of hyaluronic acid, potentially supporting filler longevity and maintaining treatment results. Lidocaine is included at 3mg/mL to reduce discomfort during injection. The patented BI-FLEX® syringe system is engineered for controlled gel extrusion, consistent injection pressure, and greater precision during facial and hand rejuvenation treatments.  Like other hyaluronic acid-based fillers, STYLAGE® M BI-FLEX® with Lidocaine can be reversed with hyaluronidase when medically indicated. How Is STYLAGE® M BI-FLEX® with Lidocaine Administered, and What Are the Safety Considerations? STYLAGE® M BI-FLEX® with Lidocaine should only be administered by qualified aesthetic professionals familiar with facial anatomy, vascular safety protocols, and complication management. Injection depth varies by indication:  Mid-dermis for wrinkle correction Mid-to-deep dermis or subcutaneous plane for volume restoration and hand rejuvenation Common techniques include linear threading, fanning, cross-hatching, and serial puncture. Lidocaine is co-formulated at 3mg/mL; a topical anesthetic may also be applied at the practitioner’s discretion. Practitioners evaluating sourcing options when buying online should confirm product authenticity, cold-chain integrity, and distributor compliance before procurement. Temporary side effects may occur following administration and are generally mild and self-limiting. Common reactions include redness, swelling, tenderness, bruising, mild itching, and temporary firmness at the injection site. Patients should avoid excessive sun exposure until any redness or swelling has resolved. Bruising may occur and typically improves within a few days. Common Side Effects Redness, swelling, tenderness, bruising, mild discomfort, and temporary firmness at the injection site are the most frequently reported reactions. These effects generally resolve within a few days. Serious Adverse Events Although uncommon, serious complications, including vascular occlusion, skin necrosis, infection, delayed inflammatory reactions, and visual disturbances, have been reported with dermal filler injections. Practitioners must be trained to recognize these events and initiate appropriate emergency management. Patients with known hypersensitivity to hyaluronic acid or active skin infections at the intended injection site should not receive treatment.  Clinicians should consult the official Instructions for Use (IFU) for complete contraindication and safety guidance. What Is the Regulatory Status of STYLAGE® M BI-FLEX® with Lidocaine? STYLAGE® M BI-FLEX® with Lidocaine is manufactured in France by Laboratories VIVACY and carries CE marking for professional aesthetic use in applicable European markets. The product is restricted to licensed medical professionals and registered aesthetic clinics trained in injectable procedures. Regulatory requirements may differ across jurisdictions, and practitioners should independently verify local approval and import regulations before clinical use. Practitioners who wish to buy dermal fillers or buy STYLAGE® may contact Medical Spa Rx’s professional support team for sourcing information and documentation support. Regulatory information is current as of May 2026; practitioners should verify local requirements before procurement or use. For sourcing guidance, contact Medical Spa Rx’s professional support team.