Pyridoxal-5'-Phosphate (Active B6)

Vitamin B6 is not one molecule but six, and only one of them does any work. Pyridoxine — the form in most supplements and most fortified food — is a precursor. The liver must phosphorylate and oxidize it before it becomes pyridoxal-5'-phosphate, the coenzyme that actually sits in the active site. That conversion depends on riboflavin, on zinc, and on functioning hepatic enzymes. When any of those falter, pyridoxine can accumulate while the active form remains scarce. Supplying P5P directly bypasses the conversion step entirely. P5P is the coenzyme for well over a hundred reactions, the majority of them involving amino acids: transamination, decarboxylation, deamination. It is required for the normal synthesis of serotonin, dopamine, GABA, and heme, and for the normal metabolism of homocysteine. Few coenzymes are so widely conscripted. This tablet is enteric-coated. P5P is somewhat unstable in stomach acid, and the coating carries it intact into the intestine, where absorption occurs. Each tablet supplies 20 mg of vitamin B6 as pyridoxal-5'-phosphate, with 103 mg calcium as tricalcium phosphate. Contains no yeast, starch, sugar, beef, milk, wheat, or other common food allergens. 100 enteric-coated tablets. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.