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Includes potent ingredients that also act as antioxidants, like green tea extract and red raspberry. Also included are natural ingredients like uva ursi, pumpkin seed and marshmallow plant. This herbal supplement is a great for a more natural option to supplement one's wellness.* Formula Purposes & Benefits Proshield is formulated to support prostate health, antioxidant activity, energy, cognition, sexual function, mood, and cardiovascular health. Our product is synthesized utilizing the latest scientific research and formulated with high-quality ingredients. Our formula is third-party independently tested for heavy metals, impurities, made in the USA, GMP certified, and produced in an FDA registered facility. 1% of the supplements on the market can match our world-class standards. Formula Ingredient Deck Benefits Of Each Ingredient Vitamin E Supports immune function, cognitive health, cardiovascular health, and bone health (204,205,206,207,208) Supports immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (204). Supports cardiovascular health via reduced cholesterol (204). Supports cognitive function via reduced oxidative stress, inflammation, and DNA damage of neuronal tissues (208). Vitamin B6 Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40). Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39). Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40). May support blood sugar regulation in women with gestational diabetes (40). Cofactor for enzymes involved in DNA metabolism (40). Zinc Supports immune function, skin health, cognitive function, and vision (172,173). Supports stimulation of the innate and adaptive immune system (172,173). Supports the activation of lymphocytes and activation of innate and T cell-mediated immunity (172,173). Supports cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172,173). Copper Supports healthy blood sugar levels, energy metabolism and cholesterol management (143,144). Selenium Supports antioxidant function, cardiovascular health, cognitive function, thyroid health, and immune health (145, 146). Combats atherosclerosis, high cholesterol (hypercholesterolemia), and type 1 diabetes (147). Supports thyroid health via decreased circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT) (146). Increases the activity of selenoproteins that decrease reactive oxygen species (inflammation), increases natural killer activity, and increases glutathione (master antioxidant) levels (145,147). Saw Palmetto Supports prostate health, cardiovascular health, and increased hair growth (133,134). Supports prostate health via anti-androgenic and anti-inflammatory effects resulting in reduced Benign prostatic hyperplasia (134). Pygeum Africanum Supports healthy testosterone levels, improves prostate health, and reduces chronic inflammation (19). Red Raspberry A natural aromatic compound derived from raspberries enhancing fat oxidation(burning) and antioxidant protective mechanisms (20). Supports suppression of lipid accumulation (fat build-up) in adipocytes (fat cells) (21). Increases total antioxidant capacity by increasing enzymes associated with decreasing reactive oxygen species (superoxide dismutase) (22). Increases natural production of master antioxidant L-Glutathione (22). Graviola Supports antioxidant function, reduces inflammation, and aids an antimicrobial agent (186,187). Supports antioxidant function via 200 phytochemicals and high concentration of alkaloids (186,187). Combats inflammation via reduced inflammatory cytokines (markers of inflammation (186,187). Green Tea Extract Potent polyphenolic antioxidant that supports blood pressure, insulin sensitivity, and metabolic health (26). High in ECGC (epigallocatechin gallate) (26). ECGC is shown to reduce body fat mass, increase fat oxidation(burning) and increase caloric expenditure during exercise (25). Potent anti-inflammatory compound supporting glutathione production and inhibition of pro-inflammatory markers (cytokines) (26). Reduces oxidative stress (chronic inflammation in the body) (26). Cat’s Claw Supports respiratory health and combats neurodegenerative disease and inflammation (188). Supports respiratory health via reduced prevalence of respiratory infections entering lung cells (inhibition of ACE2 receptor protein docking) (182). Combats neurodegenerative disease via decreased accumulation of Brian plaques (beta-amyloid plaques) (189). Broccoli Extract Supports antioxidant activity due to the high content of polyphenols and flavonoids (antioxidants) (190). Tomato Extract/Lycopene Supports prostate health, cardiovascular support, antioxidant, anti-inflammatory, and chemoprotective properties against cancer (191,192, 193). Combats inflammation via scavenging of free radicals and reduced oxidative damage of DNA. (191,192,193). Combats carcinogenesis via carcinogen-metabolizing enzymes, apoptosis (cancer cell death), anti-proliferation, pro-differentiation, and anti-lipid peroxidation activities. (193). Inhibits phosphorylation of anti-oncogenes such as p53 and Rb. It also inhibits G0/G1 and S-phase of the cell cycle (193). Stinging Nettle Supports blood sugar regulation and urinary health. Maitake, Reishi, Shitake Supports immune health, antioxidant activity, balanced estrogen levels, antiviral support, antibacterial, reduced stress, improved exercise performance, and blood sugar regulation (194,195). Supports immune health via high concentrations of betagluxans which increase natural killer cell activity and t-cell-mediated immunity (194). Reduces the concentration of inflammatory cytokines IL-1α, IL-6, IL-10 and TNF-a (inflammation markers) in macrophages (immune cells) (194). High in the amino acid L-Ergothioneine (mainly found in mushrooms) that supports longevity, decreases chronic inflammation, and antioxidant activity (194). Quercetin Supports antioxidant, anti-inflammatory, immune system defense, reduced homocysteine (allergies), reduced triglycerides, and combats bacterial infections (114,115,116). Supports immune health via reduced c-reactive protein (major inflammatory biomarker), increased neutrophil chemotaxis, macrophage phagocytosis, NK cell lytic activity and mitogen-stimulated lymphocyte (white blood cell) proliferation (114). Supports antiviral and antibacterial activity in influenza A strains H1N1 (114). Juniper Supports urinary health via the decreased prevalence of urinary tract infections. Uva Ursi Supports urinary health via the decreased prevalence of urinary tract infections (196). Buchu Supports digestive and immune health. L-Alanine Supports blood sugar regulation, immune function, and recovery from exercise (197). Supports blood sugar regulation via increased glucose uptake into skeletal muscle and improved insulin sensitivity (197). L-Glycine Supports increased nitric oxide production, improved connective tissue health, improved sleep, and increased growth hormone production (198),199). Pumpkin Seed Supports urinary health, and immune function (175). Substantial improvement in BPH/LUTS. The observed symptom relief is accompanied by a clinically significant improvement in IPSS-related (175). Cayenne Pepper Combats diarrhea, cramps, and muscle inflammation (176). Decreases muscle soreness and increases muscle strength (177). Goldenseal Supports digestive health, antibacterial activity, and antioxidant support (201, 202). Supports antioxidant function via levels of berberine (alkaloid) (201,202). Marshmallow Supports digestive health and combats sore throats (200). Combats sore throats via increased protective film on the inflamed mucosa (inflamed throat tissue) (200). Parsley Supports immune health, antioxidant activity, and aids in the detoxification process (203,204). Proper Use of This Supplement Suggested Use: As a dietary supplement take two (2) veggie capsules once a day. For best results take two 20-30 minutes before a meal with an 8 oz glass of water, or as directed by your health care professional. Our Formula Vs Other Formulas on the Market. 1. Uses third-party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility. 1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third-party tested have been removed by FDA due to high levels of heavy metals. 2. Uses high-quality nutraceuticals in an effective evidence-based and efficaciously dosed formula. 2. Uses cheap sources of nutraceuticals that contain high amounts of fillers, heavy metals, and is formulated without evidence-based dosages. 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Antioxidants (Basel, Switzerland), 10(7), 1015. https://doi.org/10.3390/antiox10071015 Evron, E., Juhasz, M., Babadjouni, A., & Mesinkovska, N. A. (2020). Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia. Skin appendage disorders, 6(6), 329–337. https://doi.org/10.1159/000509905 Kwon Y. (2019). Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia. Food science and biotechnology, 28(6), 1599–1606. https://doi.org/10.1007/s10068-019-00605-9 Gombart, A. F., Pierre, A., & Maggini, S. (2020). A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients, 12(1), 236. https://doi.org/10.3390/nu12010236 Heffernan, S. M., Horner, K., De Vito, G., & Conway, G. E. (2019). The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review. Nutrients, 11(3), 696. https://doi.org/10.3390/nu11030696 Wang, N., Tan, H. 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