Pregnenolone (25 mg) - 60 Tablets

Douglas Laboratories Pregnenolone (25 mg) Pregnenolone 25 mg contains high purity pregnenolone and is produced under strict Good Manufacturing Practices (GMP) standards. Tablets can be dissolved in mouth and swallowed or swallowed whole. Ingredients Each serving contains: Pregnenolone   -    25 mg Other ingredients: Cellulose, mannitol, stearic acid, vegetable stearate and silica Suggested Use As a dietary supplement, adults take 1/2 to 1 tablet daily as directed by your healthcare professional ONLY! Allow tablet to dissolve in mouth and then swallow More Info. Pregnenolone is often referred to as the grandparent precursor to steroid hormones in mammals. Pregnenolone is synthesized from cholesterol in the mitochondria of adrenal glands. Pregnenolone is also made to a lesser extent in the brain, liver, skin, testes and ovaries. Once synthesized, pregnenolone is released from the mitochondria into the cytosol where it can be converted to DHEA (dehydroepiandrosterone) or to progesterone. DHEA serves as a precursor compound to the androgens and the estrogens through androstenedione as the intermediate compound. Progesterone is the precursor to cortisol, aldosterone, androstenedione, estrogen, and testosterone. Pregnenolone may also be secreted directly into the blood where it circulates primarily as the sulfated form. Pregnenolone has many actions of its own not attributable to its conversion to progesterone or to DHEA. Recent studies show that pregnenolone is important for the function of brain, nervous tissue, liver, pancreas, reproductive tissues, pituitary and skin. Pregnenolone is found in higher concentrations in the central nervous system compared to the peripheral tissues which may reflect its importance in brain function. As with many hormones, pregnenolone production declines with age. It is estimated that pregnenolone production is about 60% less at age 75 than at age 35. Pregnenolone levels may also decline under various conditions of physiological stress, such as acute and chronic infections and trauma.