PLINEST® ONE

PLINEST ONE Product Description PLINEST ONE is a single-use injectable skin revitalization product powered by PN-HPT™ (Polynucleotides Highly Purified Technology), offering targeted rejuvenation in a compact 1 ml format. Manufactured by Mastelli Srl, PLINEST ONE is ideal for first-time patients, localized treatments, or maintenance sessions following full biorevitalization protocols. This sterile, non-pyrogenic, viscoelastic gel is designed to improve skin elasticity, hydration, and tone with a lower-dose application of long-chain deoxyribonucleotide polymers. As part of the PLINEST family, it carries the same regenerative technology but in a smaller format, making it efficient, practical, and cost-effective for precision treatments or touch-ups. PLINEST ONE Key Features and Benefits PLINEST ONE retains the core advantages of the PLINEST range but delivers them in a streamlined, minimal-dose format. It provides visible results in localized areas or during intermediate skin maintenance phases. Key Benefits: Convenient 1 ml syringe ideal for localized or trial treatments Maintains skin texture, firmness, and hydration Suitable for younger patients or between full treatments Utilizes PN-HPT™ for collagen stimulation and fibroblast activation Enhances skin’s receptiveness to other aesthetic therapies Promotes radiance and freshness with minimal intervention Low risk of side effects, highly biocompatible and well-tolerated PLINEST ONE Composition PLINEST ONE is based on the same high-purity ingredients used in the PLINEST line, tailored to a 1 ml dose for efficient application without sacrificing effectiveness. Composition per 1 ml syringe: Polynucleotides (PN-HPT™): 20 mg (concentration may vary between 15–20 mg/ml) Sterile, non-pyrogenic, viscoelastic carrier gel No added lidocaine, preserving purity for sensitive areas PN-HPT™ are DNA fractions extracted through advanced purification technologies, ensuring optimal biological action and minimal immunogenic risk. PLINEST ONE Intended Purpose / Indications PLINEST ONE is intended for preventive, corrective, or maintenance aesthetic treatments involving skin quality restoration, anti-aging care, and local dermal rejuvenation. It is suitable for both men and women. Indications: Early signs of skin aging Fine wrinkles, dullness, or loss of firmness Localized skin repair post-laser or peeling Periorbital, perioral, or forehead treatment Maintenance sessions following full PLINEST protocols Ideal for new patients hesitant to commit to 2 ml treatments PLINEST ONE Injection and Treatment Areas PLINEST ONE is administered intradermally into areas showing early or localized signs of skin fatigue, laxity, or poor tone. It is also useful for subtle refinement between full sessions. Treatment Areas: Eye contour Nasolabial area Lips and perioral zone Forehead Hands Décolleté Injection Depth: Intradermal Recommended Volume: 1 ml per session Technique: Micro-droplet or linear retrograde Needle Size: 30G ½ inch PLINEST ONE Reconstitution and Preparation Guidelines PLINEST ONE is supplied in a ready-to-use prefilled syringe and does not require reconstitution. Its compact size reduces waste and streamlines the treatment process. Preparation Steps: Bring product to room temperature before use Maintain aseptic technique Attach the included 30G needle Prime syringe to confirm smooth gel flow PLINEST ONE Administration and Dosage PLINEST ONE is ideal for targeted rejuvenation protocols or short-cycle sessions. It is administered by licensed professionals trained in dermal injection techniques. Typical Protocols: 1 session every 14–21 days Total of 3 sessions recommended for initial effect Followed by 1 session every 2–3 months for maintenance Injection Techniques: Micro-droplet (0.1–0.2 ml per point) Linear retrograde threading Gentle, even distribution in the dermis for uniform results PLINEST ONE Storage Instructions Proper storage preserves the safety, sterility, and performance of the product. Storage Guidelines: Store at 2°C to 25°C Do not freeze Keep away from direct sunlight and moisture Use before the expiry date on packaging PLINEST ONE Contraindications Despite its excellent safety profile, PLINEST ONE should not be used in certain medical conditions or in patients with known sensitivities. Contraindicated In: Hypersensitivity to polynucleotides Active skin infection or inflammation at the treatment site Autoimmune diseases Pregnancy or breastfeeding Bleeding disorders or use of anticoagulants PLINEST ONE Precautions and Warnings Though gentle and well-tolerated, PLINEST ONE requires attention to technique and hygiene to ensure safe outcomes. Precautions: Avoid intravascular injection Use caution near delicate vascular zones like the eyes Do not mix with other injectables in the same syringe Inject slowly and uniformly Monitor for hypersensitivity reactions within the first 24 hours PLINEST ONE Post-Treatment Care To support tissue regeneration and minimize inflammation, post-treatment guidelines should be followed carefully. Aftercare Instructions: Avoid sun exposure, heat, or cold extremes for 48 hours Refrain from makeup or active skincare for at least 12–24 hours Use cold compress if mild redness or swelling occurs Do not massage or manipulate the treated area unless advised PLINEST ONE Side Effects and Adverse Reactions PLINEST ONE is clinically tested for high tolerability. Most side effects are mild, temporary, and localized to the injection site. Common Side Effects: Mild redness or swelling Bruising or tenderness Slight itching or sensitivity Rare Side Effects: Local nodules (resolvable) Allergic reactions Vascular compromise (very rare) All adverse events should be reported and evaluated by a medical professional. PLINEST ONE Patient Eligibility PLINEST ONE is suitable for a broad range of adult patients, particularly those interested in preventative aesthetic care, targeted correction, or maintenance. Ideal Candidates: Adults 18+ with mild to moderate skin concerns Patients in between major aesthetic treatments First-time injectable patients Individuals seeking non-volumizing, regenerative results PLINEST ONE Follow-Up and Maintenance Regular maintenance is essential to extend the aesthetic and regenerative results of PLINEST ONE. Suggested Maintenance Plan: 3 sessions over 6–8 weeks for initial effect 1 session every 2–3 months thereafter Can be combined with laser, microneedling, or peels When used regularly, PLINEST ONE contributes to long-term skin tone, elasticity, and radiance. PLINEST ONE Manufacturer and Regulatory Information PLINEST ONE is produced by Mastelli Srl, a leading Italian company in regenerative medicine and biorevitalization therapies. Manufacturer Information: Company: Mastelli Srl Location: Italy Medical Classification: CE-certified Class III medical device Packaging: 1 x 1ml prefilled syringe with 30G needle Batch number and expiry date indicated on each syringe for traceability PLINEST ONE FAQ What makes PLINEST ONE different from PLINEST? PLINEST ONE contains the same active ingredient in a 1 ml format, ideal for smaller zones or maintenance. Can it be used with lasers or microneedling? Yes, PLINEST ONE works well as a priming treatment and complements energy-based devices. Is it painful? Discomfort is minimal, especially when using a fine 30G needle. When will I see results? Skin hydration and texture improve within 2–3 weeks, with visible smoothing after the second session. Who is it for? Ideal for those wanting mild correction, prevention, or enhanced skin tone without volume changes.