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Used as a pre-workout supplement to promote energy, increase focus and maintain endurance. It encourages the mind and body to respond quickly during a workout and allows more nutrition to flow through the body to your muscles. This pre-workout will not cause sleep disturbances when taken close to the end of the day. It also helps promote muscle mass development.* Formula Purposes & Benefits Pre-Workout (Fruit Punch) is synthesized to may support improved exercise performance, increased muscle protein synthesis, prevent muscle tissue breakdown, increase energy, increase cognition, enhance your pump, and take your workouts to the next level! Our product is synthesized utilizing the latest scientific research and formulated with optimal ratios of branch chain amino acids to produce world class results. Formula Ingredient Deck Benefits Of Each Ingredient Vitamin B6 pyridoxal 5'-phosphate (PLP) Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40). May support reduced plasma glucose (blood sugar levels) via inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39). Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40). May support blood sugar regulation in women with gestational diabetes (40). Cofactor for enzymes involved in DNA metabolism (40). Niacin (Vitamin B3) Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reduced very-low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (8,9,10,11). May support reduced conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (8,9,10,11). Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (8,9,10,11). May support healthy inflammatory responses via antioxidant and anti-apoptotic (prevention of cell death) properties (8,9,10,11). May support cognitive health by reducing the age-related decline of NAD+, increasing quinolinic acid, and reducing neuroinflammation (8,9,10,11). Increased niacin-associated NAD+ levels have been shown to support neurotransmission, learning, and memory (8,9,10,11). Niacin may reduce the prevalence of neurodegenerative pathologies by supporting mitochondrial dysfunction (8,9,10,11). Caffeine Anhydrous May support optimized energy, cognitive function, and mental alertness (24). Supplementation with caffeine has been shown to acutely enhance exercise performance (24). L-Citrulline Malate May support cardiovascular health and exercise performance by increasing the production of l-arginine (34). May support increased nitric oxide production, improved exercise performance, and increased blood flow to exercising skeletal muscle (35). May support strength increases, exercise endurance, and recovery (34,35). May support reduced blood pressure by increasing vascular function (34). Bioperine Increases absorption of amino acids and curcumin. Folate (Folic Acid) May support proper cell growth and DNA synthesis (65). Vitamin B-12 (Methylcobalamin) May support proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (51,53). Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51). May support reduced vitamin b-12 deficiency pathologies such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (53). Creatine Monohydrate May support exercise performance, muscle mass, strength, thermoregulation, recovery, and intramuscular stores of phosphocreatine (PCr) (47). Vital for the energy reaction of every cell in the human body as a spatial energy shuttle and energy sensor (47,50). Vital in bioenergetics (metabolic activity) of the brain (50). Fuels CD8 and CD4 T- cell-mediated immunity (immune cells) in cancer tissue (48,49). May support cognition and focus via replenishment of cerebral storage of creatine (creatine in the brain) (50). May support cognitive health in brain creatine deficiency associated with neurodegenerative diseases (50). May support cognitive health by enhancing the facilitation of synaptic glutamate and neurotransmitter uptake (50). N-Acetyl Tyrosine May support memory, cognitive flexibility, the executive function of the brain, and convergent thinking (60). The precursor to dopamine and is vital for dopamine synthesis in the brain (60). May support cognitive function in individuals with high amounts of stress and anxiety (60,61). May support increased dopamine levels in highly stressed individuals (60). Choline Bitrate Essential for cell membrane integrity, cell messaging, fat metabolism, DNA synthesis, immune support, and nervous system function (62,63). Serves as a methyl donor and as a precursor for production of cell membranes (62). Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system mediated immune responses (α7nAchR) (64). Lifelong choline supplementation may combat neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (62). May support reduced concentration of total homocysteine (inflammation marker) in individuals with low levels of folate and other B vitamins (B₂, B₆, and B₁₂) (62). DMAE Bitrate May support increased acetylcholine levels in the brain. L-Theanine May support hydration, increased energy, antioxidant function, and increases fat metabolism during aerobic exercise (242,243). May support antioxidant function via combating reactive oxygen species (243). May support increased fat metabolism during exercise via enhanced mitochondrial fatty acid oxidation (cells using fat as fuel) (242). Bacopa Monnieri May support cognitive function, memory, alertness, and aids as an anti-stress agent (57). Bacopa has been shown to have anti-inflammatory effects on macrophages (immune cells) and inhibits the release of IL-6 and TNF-α (inflammatory markers) from monocytes (immune cells) (58,59,). A promising potential candidate for the development of novel therapeutics that may target neuroinflammation and have the potential for supporting a wide range of CNS disorders including Alzheimer's disease, depression, and schizophrenia (59). Proper Use of This Supplement Suggested Use: Stir 1 rounded scoop with 6-8ounces of cold water and consume 30-45 minutes before beginning activity. Our Formula Vs Other Formulas on the Market. 1. Uses third-party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility. 1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third-party tested have been removed by FDA due to high levels of heavy metals. 2. Utilizes efficacious evidence-based dosages with optimal ratios of amino acids, nootropics, and pump enhancers to support exercise performance and recovery. 2. Use low amounts of cheap forms of amino acids, nootropics, and pump enhancers that result in poor absorption and muscle growth, recovery, and exercise performance. Sources: Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1. https://doi.org/10.1186/s12970-020-00383-4 Barkhidarian, B., Khorshidi, M., Shab-Bidar, S., & Hashemi, B. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna journal of phytomedicine, 9(1), 10–20. Figueroa, A., Wong, A., Jaime, S. J., & Gonzales, J. U. (2017). Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Current opinion in clinical nutrition and metabolic care, 20(1), 92–98. https://doi.org/10.1097/MCO.0000000000000340 Bahri, S., Zerrouk, N., Aussel, C., Moinard, C., Crenn, P., Curis, E., Chaumeil, J. C., Cynober, L., & Sfar, S. (2013). Citrulline: from metabolism to therapeutic use. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 479–484. https://doi.org/10.1016/j.nut.2012.07.002 Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., … Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. doi:10.1186/s12970-017-0173-z Di Biase, S., Ma, X., Wang, X., Yu, J., Wang, Y. C., Smith, D. J., Zhou, Y., Li, Z., Kim, Y. J., Clarke, N., To, A., & Yang, L. (2019). Creatine uptake regulates CD8 T cell antitumor immunity. The Journal of experimental medicine, 216(12), 2869–2882. https://doi.org/10.1084/jem.20182044 Kazak, L., & Cohen, P. (2020). Creatine metabolism: energy homeostasis, immunity and cancer biology. Nature reviews. Endocrinology, 16(8), 421–436. https://doi.org/10.1038/s41574-020-0365-5 Ebrahimi, K., Jourkesh, M., Sadigh-Eteghad, S., Stannard, S. R., Earnest, C. P., Ramsbottom, R., Antonio, J., & Navin, K. H. (2020). Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer's Diseases. Diseases (Basel, Switzerland), 8(2), 18. https://doi.org/10.3390/diseases8020018 van de Lagemaat, E. E., de Groot, L., & van den Heuvel, E. (2019). Vitamin B12in Relation to Oxidative Stress: A Systematic Review. Nutrients, 11(2), 482. https://doi.org/10.3390/nu11020482 Romain, M., Sviri, S., Linton, D. M., Stav, I., & van Heerden, P. V. (2016). The role of Vitamin B12 in the critically ill--a review. 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(2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020 Nemetchek, M. D., Stierle, A. A., Stierle, D. B., & Lurie, D. I. (2017). The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain. Journal of ethnopharmacology, 197, 92–100. https://doi.org/10.1016/j.jep.2016.07.073 Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N., & Norman Scholfield, C. (2014). Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of ethnopharmacology, 151(1), 528–535. https://doi.org/10.1016/j.jep.2013.11.008 Sukumaran, N. P., Amalraj, A., & Gopi, S. (2019). 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Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation. Aging cell, 18(6), e13037. https://doi.org/10.1111/acel.13037 Jadavji, N. M., Emmerson, J. T., MacFarlane, A. J., Willmore, W. G., & Smith, P. D. (2017). B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke. Neurobiology of disease, 103, 89–100. https://doi.org/10.1016/j.nbd.2017.04.001 Jacobson, S. W., Carter, R. C., Molteno, C. D., Stanton, M. E., Herbert, J. S., Lindinger, N. M., Lewis, C. E., Dodge, N. C., Hoyme, H. E., Zeisel, S. H., Meintjes, E. M., Duggan, C. P., & Jacobson, J. L. (2018). Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. 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