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This supplement helps by improving mental clarity and focus, boosting intelligence levels, memory function, and increasing your level of concentration and alertness. As an added bonus, Neuro Plus can provide you with an increased level of energy and improved mood.* Formula Purposes & Benefits Neuro Plus Brain and Focus is formulated to boost cognitive function, mental clarity, focus, immune function, and energy production. Our product is synthesized utilizing the latest scientific research and formulated with high-quality ingredients. Formula Ingredient Deck Benefits Of Each Ingredient Vitamin A May support vision health, skin health, immune health, and increases antioxidant support (182, 183). May support antioxidant function via decreased inflammatory cytokines (inflammation), decreased reactive oxygen species, and increased L-glutathione production (master antioxidant) (182, 183). May support visual health via increased amounts of plasma vitamin A in macular (eye) tissues (182,183). Vitamin C May support immune, cardiovascular, skin, cognitive, fat burning, and digestive health (97, 98). May support immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97,98). May support fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97,98). May support accelerated bone healing after a fracture, increased type I collagen synthesis, and reduced oxidative stress (inflammation) (98). Vitamin D May support exercise performance, immune health, muscle growth, optimal bone health, hormonal health, immune function, increased sexual health, cardiovascular health, glucose tolerance, increased strength, and positive mood (77,78,79). May support hormonal health via high amounts of vitamin D receptor (VDR) activity in hormone based negative feedback loop reactions (77,78). May support cardiovascular health via improved absorption of calcium, reduced atherosclerotic activity, stimulating cardiomyocytes, and improved vascular health (77,78). May support exercise recovery via reduced post exercise inflammation and muscle damage (77,78). May support sexual health via increased activity of Vitamin D receptor activity of testosterone production (79). May support immune function via decreases of inflammatory cytokines and aiding immune cells (77,78). May support joint health via regulating calcium and phosphorus and bone remodeling along with other calcium-regulating actions (77,78). Vitamin E May support immune function, cognitive health, cardiovascular health, and bone health (204,205,206,207,208) May support immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (204). May support cardiovascular health via reduced cholesterol (204). May support cognitive function via reduced oxidative stress, inflammation, and DNA damage of neuronal tissues (208). Vitamin B1 (Thiamine) May support aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94). May support cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95). Vitamin B2 (Riboflavin) May support conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92,93). Vitamin B3 (Niacin) Major B vitamin that may support cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very-low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9). Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9). Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9). May support healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9). May support reduced prevalence of pellagra, nervous anorexia, and Crohn’s disease (10, 11). Vitamin B6 Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40). May support reduced plasma glucose (blood sugar levels) via inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39). Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40). May support blood sugar regulation in women with gestational diabetes (40). Cofactor for enzymes involved in DNA metabolism (40). Folic Acid May support proper cell growth and DNA synthesis (65). Biotin May support conversion of food into cellular energy, hair health, skin health, and cognitive function (213,214). May support glucose breakdown into skeletal muscle tissue (213,214). Vitamin B5 May support energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96). Calcium May support bone health, muscle function, and cardiovascular health (36,37). Regulates processes of bone resorption, mineralization, and fracture repair (36,37). Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37). May support reduced prevalence of preeclampsia (36,37). Iron May support red blood cell formation, immune function, and antioxidant support (215,216). May support increased oxygen uptake into red blood cells of Iron deficient individuals (215,216). May support gut health of iron-deficient individuals. May support reduced prevalence of anemia in Iron deficient individuals (217). Magnesium May support optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90,91). Supports biological reactions such as ATP-fueled reactions and pancreatic insulin secretion (90,91). May support reduced systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90,91). May support reduced peripheral cortisol levels in the CNS and supports relaxation and decreased anxiety (90,91). Zinc May support immune function, skin health, cognitive function, and vision (172,173). May support stimulation of the innate and adaptive immune system (172,173). May support the activation of lymphocytes and activation of innate and T cell-mediated immunity (172,173). May support cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172,173). Selenium May support antioxidant function, cardiovascular health, cognitive function, thyroid health, and immune health (145, 146). May support reduced prevelance of atherosclerosis, high cholesterol (hypercholesterolemia), and type 1 diabetes (147). May support thyroid health via decreased circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT) (146). Increases the activity of selenoproteins that decrease reactive oxygen species (inflammation), increases natural killer activity, and increases glutathione (master antioxidant) levels (145,147) Copper May support healthy blood sugar levels, energy metabolism and cholesterol management (143,144) Manganese May support enzymatic antioxidant reactions, increased bone mineral density, and blood sugar regulation (148,149). Chromium May support insulin function, reduced cholesterol, improved blood sugar regulation, and may lower cholesterol (218,219). Molybdenum May support increased enzymatic reactions involved in sulfite metabolism and detoxification (150). DMAE Bitartrate May support increased acetylcholine levels in the brain. L-Glutamine The most abundant amino acid in skeletal muscle that fuels immune cells, may support improved exercise recovery, and optimized gut microbiome (18). Vital for lymphocyte (immune cell) proliferation (growth) and paramount in neutrophil (immune cell) destruction of bacteria (18). Vital for activation of genetic signals that support immune function and vitality (18). Glutamine is utilized by immune cells at high rates during catabolic conditions (post-surgery, sepsis, burns, and extreme exercise (18). Glutamic Acid May support cognitive function and focus (220). Green Tea Extract A potent polyphenolic antioxidant that may support blood pressure, insulin sensitivity, and metabolic health (25). High in ECGC (epigallocatechin gallate) (25). ECGC is shown to reduce body fat mass, increase fat oxidation(burning) and increase caloric expenditure during exercise. (25). Potent anti-inflammatory compound that may support glutathione production and inhibition of pro-inflammatory markers (cytokines). (26). May support reduced oxidative stress (chronic inflammation in the body) (26). Choline Essential for cell membrane integrity, cell messaging, fat metabolism, DNA synthesis, immune support, and nervous system function (62,63). Serves as a methyl donor and as a precursor for the production of cell membranes (62). Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system-mediated immune responses (α7nAchR) (64). Lifelong choline supplementation may support reduced prevalence of neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (62). May support immune health via reduced concentrations of total homocysteine (inflammation marker) in individuals with low levels of folate and other B vitamins (B₂, B₆, and B₁₂) (62). Inositol May support liver detoxification, reduced prevalence of metabolic syndrome, and aids as an antioxidant (221). May supported reduced prevalence of metabolic syndrome via reduced levels of triglycerides, total- and LDL-cholesterol (221). May support antioxidant function via reduced levels of reactive oxygen species and inflammatory markers (interleukin 6) (222). N-Acetyl Tyrosine May support memory, cognitive flexibility, the executive function of the brain, and convergent thinking (60). The precursor to dopamine and is vital for dopamine synthesis in the brain (60). May support cognitive function in individuals with high amounts of stress and anxiety (60,61). May support increased dopamine levels in highly stressed individuals (60). Bilberry Fruit May support vision health, cardiovascular function, increased nitric oxide production, and antioxidant support (223,224). Grape Seed Extract May support increased nitric oxide production, reduces blood pressure, reduces DNA damage, increases collagen production, increases bone strength, and aids as a neuroprotective agent (31). May support antioxidant function via modulation of antioxidant enzyme expression, protection against oxidative damage, and reduced reactive oxygen species (31). May support cardiovascular health via reduced atherosclerosis, inhibiting lipid peroxidation, and improved endothelial vascular function (31). Olive Leaf May support cardiovascular health, antioxidant function, and controlled blood sugar levels (224). May support cardiovascular health via reduction of systolic BP, LDL, and inflammatory biomarkers (224). May support antioxidant function via anti-inflammatory polyphenols that protect against DNA damage initiated by free radicals (225). Supports immune health via reduced inflammatory pathway activation (NF-κB inhibition) (225). May support blood sugar regulation via improved insulin sensitivity and pancreatic β-cell (cells responsible for secreting insulin) secretory capacity (226). Licorice Root May support anti-inflammatory, anti-allergenic, and antimicrobial properties (177). Boron May support increased bone mineral density, muscle function, hormonal balance, and immune function (180). DHA (Fish Oil) Vital for optimal cardiovascular, hormonal, immune, cognitive, digestive health, and recovery from exercise (73,74,76). Fish oil consumption of 6 grams per day has been shown to may reduce inflammation, reduce muscle soreness, and reduce the perception of pain in exercising individuals (76). May support increased skeletal muscle hypertrophy individuals consuming only whey protein post-exercise (76). May support cardiovascular health by decreasing atrial fibrillation, atherosclerosis (plaque buildup), thrombosis, blood pressure, and supporting blood lipid profiles (cholesterol panel) (73,74,75). May support lowered blood pressure via increased nitric oxide production and induced endothelial relaxation (75). May support healthy inflammation levels by decreasing c-reactive protein (inflammatory markers) in the body and increasing insulin sensitivity (75,76). May support cognitive health by increasing the concentration of omega 3 fatty acids in the cell membranes of the cerebral cortex and synaptic vesicles (76). Vanadyl Sulfate May support blood sugar regulation via improved insulin sensitivity and pancreatic beta-cell function (cells that produce insulin) (227). Phosphatidylserine May support cognitive function, memory, and focus, and reduce stress (228,229). May support reduced prevalence of short-term memory loss in ADHD patients improved prefrontal cortex (PFC) pyramidal cells function (228). <spa
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