Matrixyl

Matrixyl aka Palmitoyl Pentapeptide-4. 100mg Raw peptide, no fillers. Naturally occurring peptides in the skin perform critical roles in skin maintenance and repair, and there is growing interest in harnessing these effects for therapeutic and cosmetic use. Pentapeptide-4 (former pentapeptide-3) is a 5 amino acid length fragment of pro-collagen I (lysine-threonine-threonine-lysine-serine; KTTKS; Micro-Collagen™) protein that stimulates dermal matrix components production by skin fibroblasts. However, delivering KTTKS across the skin was challenging, given its ionic nature. Matrixyl™ (Palmitoyl pentapeptide-4; former Palmitoyl pentapeptide-3) is the palmitoyl derivative of this pentapeptide (pal-KTTKS) and is more stable and active for topical application thanks to lipophilic conjugate from palmitic acid resulted from research aimed at enhancing peptide delivery while maintaining bioactivity, mildness, and skin benefit potency. Other data show that pal-KTTKS stimulates collagen synthesis and other dermal matrix components, suggesting possible mechanisms for its skin benefits. In vitro and acute in vivo testing indicates that pal-KTTKS also inhibits excess production of dermal glycosaminoglycans (GAGs) associated with aging skin and induces epidermal thickening, effects which also likely contribute to its clinical benefits. Multiple chronic human tests with topical application pal-KTTKS lipo-peptide demonstrate improvement in the appearance of facial skin wrinkles without the irritation associated with technology such as retinol, confirming other reported small base testing of this ingredient. Reduction of the appearance of human facial skin wrinkles determined by expert graders, image analysis, and subject self-assessment. The improvement in wrinkle appearance is achieved without the increased skin redness or barrier damage associated with other antiaging actives. In self-assessments, subjects also reported there was a significant improvement in their facial wrinkles, and they also reported small but significant improvements in age spots, dark circles, and skin firmness. Other data show that Matrixyl™ stimulates collagen synthesis and other dermal matrix components, suggesting possible mechanisms for its skin benefits. Tests have revealed that pal-KTTKS also inhibits excess production of dermal glycosaminoglycans (GAGs) associated with aging skin and induces epidermal thickening, effects which also likely contribute to its clinical benefits.