HMF™ Multi Strain (shelf-stable) - 50 Capsules

Description Genestra HMF™ Multi Strain (shelf-stable)  16-strain probiotic combination Provides 15 billion CFU per capsule from a combination of 16 strains Supports gastrointestinal health, abdominal comfort and a healthy microflora Balances microflora composition No refrigeration necessary Potency guaranteed through expiration HMF™ Multi Strain offers a comprehensive combination of 16 probiotic strains that promote a healthy gut microflora. Each shelf-stable capsule provides a variety of strains to promote colonization in both the small and large intestines. HN019, a probiotic strain included in this formula, was shown in a placebo-controlled trial to promote a healthy gut microflora. It significantly increased Bifidobacteria and Lactobacilli counts, while reducing the population of Enterobacteria (a genus that includes many pathogenic bacteria). Similarly, Genestra's HMF™ probiotic consortium, Lactobacillus acidophilus (CUL-60 and CUL-21), Bifidobacterium bifidum (CUL-20) and Bifidobacterium animalis subsp. lactis (CUL-34), contained in HMF™ Multi Strain, has been demonstrated in clinical trials to support abdominal comfort and promote a healthy microflora balance in the gastrointestinal tract. This convenient shelf-stable format has potency guaranteed through expiration and may improve patient compliance. Ingredients Serving Size: 1 Vegetarian Capsule Amount/Serving Probiotic Consortium 15 billion CFU Lactobacillus acidophilus (CUL-60 & CUL-21) Bifidobacterium animalis subsp.lactis (CUL-34)                           & Bifidobacterium bidum (CUL-20) Lactobacillus salivarius (CUL-61) Lactobacillus fermentum (CUL-67) Lactobacillus gasseri (CUL-09) Lactobacillus acidophius (NCFM®) Lactobacillus casei (CUL-06) Lactobacillus paracasei (CUL-08) Bifidobacterium animalis subsp. lactis (CUL-62) Bifidobacterium breve (CUL-74) Bifidobacterium animalis subsp. lactis (HN019) Lactobacillus plantarum (CUL-66) Streptoccus salivarius subsp. thermophilus (CUL-68) Lactobacillus rhamnosus (HN001) Other Ingredients: Microcrystalline cellulose, hypromellose, sunflower lecithin, silica.  Dairy Free. Gluten Free. GMO Free. Soy Free. Vegan. No FOS. NCFM® is used with permission under license.  Suggested Use Adults, Adolescents and Children (6 years and older): Take 1 capsule daily or as recommended by your health professional.  WARNING: If you have an immune-compromised condition, do not use. If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use. If symptoms of digestive upset occur, stop use and consult your health professional. Keep out of the reach of children. This product was sealed for your protection. Do not use if box or contents are open or damaged. Storage: Store in a cool, dry place. More Info.  Genestra HMF™ (Human Microflora) Probiotics offer:  Clinically studied, proprietary strains Doctor-recommended for over 20 years Research-driven, condition-specific formulas Potency guaranteed through expiration  The human intestinal tract contains more than 400 bacterial species. This microflora composition can be altered by a number of factors, including diet, occasional stress, certain medications, aging and travel. When the microflora balance is affected in the intestines, common gastrointestinal complaints can occur, including mild bloating and gas. Probiotics are defined by the World Health Organization as "live microorganisms which when administered in adequate amount confer a health benefit on the host. Probiotics have been found to support gastrointestinal health and contribute to a healthy microflora composition. Studies have shown that they mediate microbial colonization and support the growth of beneficial bacteria in the intestines. Probiotics accomplish this by mediating intestinal pH and strengthening the epithelial barrier. They mediate the integrity of tight junctions and increase mucin release, which in turn regulates permeability and reduces microbial adherence to cells.  HMF™ Multi Strain is formulated using probiotic strains that have been used in a wide body of clinical research, including HN019, NCFM®, and Genestra Brands® HMF™ proprietary Lactobacillus and Bifidobacterium probiotic consortium. Studies demonstrate that these strains effectively contribute to a healthy gut flora and support gastrointestinal health.  Microflora Composition In one randomized, double-blind, placebo-controlled trial, supplementation with HN019 significantly contributed to a favorable gut flora in aging adults. Elderly participants (over 60 years of age) consumed either a placebo or one of three probiotic supplements daily for four weeks [low (6.5x10 CFU), medium (1.0x10 CFU) or high (5.0x10)]. Probiotic supplementation significantly increased the mean number of fecal Bifidobacteria when compared to baseline levels. As the levels of Bifidobacteria naturally decrease with age, supplementation with HN019 may represent an easy way to promote its proliferation in the intestines.  In addition, HN019 intake significantly increased Lactobacilli and Enterococci counts in the high and medium groups after four weeks. As Bifidobacteria produce acetate and lactate, they may also help to support the growth of Lactobacilli.  The HMF™ Probiotic consortium was found to modulate the intestinal microflora composition in a double-blind, placebo-controlled trial. Participants were divided into two groups, receiving either a probiotic or placebo supplement for 21 days. Fecal samples were collected at baseline (day one) and on days 7 and 35 to determine the average bacterial composition. Each probiotic capsule was taken once daily and contained 2.5x10 CFU from a combination of two strains of Lactobacillus acidophilus (CUL-60 and CUL-21), Bifidobacterium animalis subsp. lactis (CUL-34), and Bifidobacterium bifidum (CUL-20). HMF probiotic supplementation helped to support the growth of beneficial strains and maintain a healthy microflora balance in adults.  Intestinal Transit Time In a placebo-controlled trial, daily supplementation with HN019 for two weeks significantly improved whole gut transit time (WHTT) and gastrointestinal comfort and function scores. One hundred adults were randomized to one of three groups, consuming placebo, low- (1.8 billion CFU of HN019) or high-dose probiotic (17.2 billion CFU of HN019) capsules daily for two weeks. WGTT was determined using abdominal X-ray scans at baseline and after two weeks of supplementation. Gastrointestinal comfort and function scores were also analyzed between baseline and study completion. Supplementation with HN019 was dose-dependently associated with a significant improvement in WGTT (25% and 33% decrease for the low-and high-dose groups., respectively). Probiotic supplementation also significantly improved both upper (abdominal discomfort, gurgling) and lower (occasional constipation, bowel movement regularity and flatulence) gastrointestinal comfort function and scores. Similarly, a randomized, double-blind, placebo-controlled study found that combined supplementation with HN019 and Lactobacillus acidophilus NCFM® for two weeks significantly reduced transit time compared to the control group.  In an eight-week long, double-blind, randomized, placebo-controlled study involving 52 adults, supplementation with a combination of four HMF™ probiotic strains significantly reduced mild intestinal discomfort. Participants were randomized to either the placebo or probiotic capsule group (25 billion CFU from CUL-60, CUL-21, CUL-34 and CUL-20) and consumed one capsule daily for eight weeks. Participants scored their intestinal discomfort (including bloating, satisfaction with bowel habits and quality of life) at baseline and every two weeks during the supplementation period. In comparison with baseline values, probiotic supplementation significantly improved intestinal discomfort scores, including a 22% decrease in days with intestinal discomfort, 32% improvement in satisfaction with bowel habits and 30% improvement in quality of life scores. These improvements were also significantly greater when compared to placebo values.