Cosmoperine®

Cosmoperine®, also known as tetrahydropiperine (THP), is derived from piperine, the active principle of black peppercorns (Piper nigrum) which acts as a penetration enhancer when added to water soluble ingredients. It works by enhancing the bioavailability of nutrients, including vitamins, minerals, coenzymes, and nutraceutical herbal extracts. An increase in topical permeation was shown when combining Cosmoperine with products like Green Tea extract; an antioxidant rich in polyphenols, Coleus Forskohlli Extract; a skin conditioning agent and Tetrahydrocurcumin; derived from Curcuminoids as extracted from Turmeric Root, acting as a potent antioxidant. One study showed an enhanced absorption of 30% in Vitamin C and Beta Carotene. While at present there is insufficient experimental data to determine the actual mechanism of THP’s bioenhancing properties, it is postulated that THP may operate by increasing either the membrane’s fluidity and/or the affinity of the nutrient to the cell membrane. THP is also a lipophilic compound and may therefore increase solubilization of the intracellular lipid moiety in the skin, making it more permeable to the applied nutrient. INCI: Tetrahydropiperine Cosmoperine® is a patented product of Sabinsa Corporation. California Prop 65 Statement: The following statement is made in order to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects or other reproductive harm. SDS & Tech Data Cosmoperine® as Enhancer of Nutrient and Drug Bioavailability Cosmoperine SDS Formulation Guide Recommended Usage Rate: 0.001-0.1% (w/w) Appearance: White powder Solubility: Soluble in Dimethyl Isosorbide (2 parts DMI to 1 part Cosmoperine), Ethoxydiglycol and ethanol, partially soluble in propylene glycol, insoluble in water and glycerin Storage: Store in cool, dry place in original container away from light and moisture Shelf life: 4 years, 11 months, properly stored.