ACE-031

ACE-031 Chemical Information: Chemical Name: ActRIIB-Fc fusion protein (Activin Receptor Type IIB / IgG1-Fc); also referenced as ACVR2B-Fc Molecular Weight: ~80 kDa (homodimeric); ~58 kDa per glycosylated monomer (apparent, SDS-PAGE) Structure: Recombinant homodimeric fusion protein; 343-amino-acid monomer with N-glycosylation sites Compound Class: Recombinant fusion protein (soluble decoy receptor) Product Description: ACE-031 is a recombinant fusion protein composed of the extracellular domain of the human activin receptor type IIB (ACVR2B) linked to the Fc region of human immunoglobulin G1 (IgG1). Unlike synthetic peptides, ACE-031 is a large glycosylated protein produced through mammalian cell expression systems rather than solid-phase peptide synthesis. This product is a research-grade reagent and is not manufactured under GMP conditions; it is not equivalent to, or a substitute for, any clinical- or pharmaceutical-grade material. It is supplied as a lyophilized protein intended exclusively for controlled in-vitro laboratory research by qualified professionals studying activin/TGF-β superfamily signaling pathways. This product is not formulated for clinical, diagnostic, or therapeutic use. Research Applications: In-vitro investigation of ActRIIB ligand-trap binding interactions within the TGF-β superfamily Laboratory studies of myostatin (GDF-8) and activin signaling in cell-based assay systems Comparative evaluation of fusion-protein decoy receptors and ligand-sequestration models Analytical method development and reference characterization for recombinant fusion proteins Storage and Handling: Store lyophilized protein at -20 °C to -80 °C for long-term stability Reconstituted solutions should be stored at 2–8 °C and used promptly; avoid repeated freeze–thaw cycles Protect from light and elevated temperatures Handle using appropriate laboratory safety and aseptic techniques Product Specifications: Purity: ≥95% (SDS-PAGE / SEC, refer to Certificate of Analysis) Appearance: White lyophilized protein Solubility: Soluble in suitable laboratory agents Form: Lyophilized protein Compliance Notice: ACE-031 is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.